⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzoic Acid SCHEMBL614423 | 0.92 | — | — | |
| SCHEMBL5278917 | 0.78 | — | — | |
| SCHEMBL9133345 | 0.77 | GPR4 (0.53) | — | |
| SCHEMBL27959183 | 0.77 | — | — | |
| SCHEMBL14409680 | 0.76 | — | — | |
| Benzoic Acid SCHEMBL27952668 | 0.76 | — | — | |
| SCHEMBL7383880 | 0.75 | GPR4 (0.51) | — | |
| Benzoic Acid SCHEMBL8365322 | 0.75 | — | — | |
| Methylamine SCHEMBL9307845 | 0.74 | — | — | |
| SCHEMBL13743046 | 0.72 | AGTR1 (0.66) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4309673-A2 | FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHODS OF USE | Bausch Health Ireland Limited (IE) | 2024-01-24 | — | — | EP | disclosed |
| EP-3708179-A1 | FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHODS OF USE | Bausch Health Ireland Limited (IE) | 2020-09-16 | — | — | EP | disclosed |
| EP-2825188-B1 | FORMULATIONS OF GUANYLATE CYCLASE C AGONISTS AND METHODS OF USE | BAUSCH HEALTH IRELAND LTD (IE) | 2020-03-04 | — | — | EP | disclosed |
| EP-3239170-A1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | Synergy Pharmaceuticals Inc. (US) | 2017-11-01 | — | — | EP | disclosed |
| EP-2810951-B1 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders | SYNERGY PHARMACEUTICALS INC (US) | 2017-03-15 | — | — | EP | disclosed |
| EP-2296685-B1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | SYNERGY PHARMACEUTICALS INC (US) | 2015-09-02 | — | — | EP | disclosed |
| EP-2810951-A2 | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders | Synergy Pharmaceuticals Inc. (US) | 2014-12-10 | — | — | EP | disclosed |
| EP-2328910-B1 | AGONISTS OF GUANYLATE CYCLASE USEFUL FOR THE TREATMENT OF GASTROINTESTINAL DISORDERS, INFLAMMATION, CANCER AND OTHER DISORDERS | SYNERGY PHARMACEUTICALS INC (US) | 2014-08-06 | — | — | EP | disclosed |