Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 18/20 | 0.52 |
| ▸ | MAPT | P10636 | 13/20 | 0.52 |
| ▸ | TP53 | P04637 | 6/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15911454 | 0.97 | GAA (0.55) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL15911664 | 0.93 | GAA (0.49) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL15911618 | 0.89 | GAA (0.53) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL2809753 | 0.87 | GAA (0.50) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL2812308 | 0.81 | GAA (0.47) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL2810004 | 0.80 | TUBB4A (0.41) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL15911422 | 0.79 | GAA (0.47) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL2809857 | 0.79 | ALOX15 (0.36) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL2812288 | 0.78 | GAA (0.45) | GAAMAPTTP53MAPK1KMT2A | |
| SCHEMBL15911712 | 0.78 | GAA (0.52) | GAAMAPTTP53MAPK1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2195322-B1 | IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES FOR TREATING DISEASES SUCH AS DIABETES | MERCK PATENT GMBH (DE) | 2014-08-06 | — | — | EP | claimed |
| EP-2195322-B1 | IMIDAZO[1,2-A]PYRIMIDINE DERIVATIVES FOR TREATING DISEASES SUCH AS DIABETES | MERCK PATENT GMBH (DE) | 2014-08-06 | — | — | EP | disclosed |