Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 11/20 | 0.41 |
| ▸ | CDK2 | P24941 | 11/20 | 0.41 |
| ▸ | CDK4 | P11802 | 10/20 | 0.41 |
| ▸ | CCND1 | P24385 | 10/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.37 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.36 |
| ▸ | CASK | O14936 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | CDKL5 | O76039 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | CDK14 | O94921 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | MAK | P20794 | 1/20 | 0.36 |
| ▸ | CDK11B | P21127 | 1/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | CLK1 | P49759 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2680449 | 0.88 | MAPK14 (0.43) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL703045 | 0.86 | MAPK14 (0.51) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL708407 | 0.86 | MAPK14 (0.43) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL704772 | 0.85 | CDK2 (0.44) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL31448368 | 0.85 | CDK2 (0.44) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL702868 | 0.84 | MAPK14 (0.46) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL698984 | 0.84 | MAPK14 (0.43) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL708901 | 0.83 | MAPK14 (0.43) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL702396 | 0.83 | MAPK14 (0.43) | MAPK14CDK1CDK2CDK4CCND1 | |
| SCHEMBL704347 | 0.83 | MAPK14 (0.43) | MAPK14CDK1CDK2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421864-B1 | 1-PYRAZOLO[4,3-C]ISOQUINOLINE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI SA (FR) | 2014-08-06 | — | — | EP | claimed |