Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.44 |
| ▸ | NPY5R | Q15761 | 5/20 | 0.43 |
| ▸ | TNKS | O95271 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.40 |
| ▸ | WNT3A | P56704 | 1/20 | 0.40 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 6/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | APP | P05067 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14153754 | 0.86 | KMT2A (0.54) | KMT2AL3MBTL1SMPD3NPY5RTNKS | |
| SCHEMBL6861541 | 0.86 | KMT2A (0.57) | KMT2AL3MBTL1SMPD3NPY5RTNKS | |
| SCHEMBL25220187 | 0.76 | SMPD3 (0.49) | KMT2AL3MBTL1SMPD3NPY5RTNKS | |
| SCHEMBL14153752 | 0.76 | SMPD3 (0.49) | KMT2AL3MBTL1SMPD3NPY5RTNKS | |
| SCHEMBL11844688 | 0.73 | TNKS2 (0.50) | KMT2AL3MBTL1SMPD3TNKSPARP1 | |
| SCHEMBL31288988 | 0.68 | ALDH1A1 (0.49) | L3MBTL1SMPD3NPY5RPARP1KDM4E | |
| SCHEMBL22408471 | 0.68 | ALDH1A1 (0.49) | L3MBTL1SMPD3NPY5RPARP1KDM4E | |
| SCHEMBL1032502 | 0.68 | TNKS2 (0.68) | KMT2AL3MBTL1TNKSPARP1WNT3A | |
| SCHEMBL12492799 | 0.66 | PDCD1 (0.68) | KMT2AL3MBTL1NPY5RKDM4EALDH1A1 | |
| SCHEMBL8319716 | 0.66 | PDCD1 (0.53) | KMT2AL3MBTL1NPY5RKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2014-08-07 | — | — | US | disclosed |
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221332-A1 | METABOTROPHIC GLUTAMATE RECEPTOR 5 MODULATORS AND METHODS OF USE THEREOF | GRM5, GRIK5, GRM2 | KMT2A 2480/4885L3MBTL1 3739/4885SMPD3 2019/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.