Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C3 | P42330 | 10/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 10/20 | 0.39 |
| ▸ | PTGER4 | P35408 | 7/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.33 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | TNF | P01375 | 1/20 | 0.33 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2299042 | 0.95 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590574 | 0.94 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1589945 | 0.93 | PTGER4 (0.45) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590275 | 0.90 | PTGER4 (0.38) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590684 | 0.90 | AKR1C3 (0.39) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590400 | 0.90 | AKR1C3 (0.41) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590570 | 0.90 | PTGER4 (0.40) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL2299558 | 0.87 | PTGER4 (0.48) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 | |
| SCHEMBL1590623 | 0.86 | PTGER4 (0.48) | PTGER4CYP1A2CYP2D6HTR1AADRA1A | |
| SCHEMBL2299894 | 0.86 | AKR1C3 (0.43) | AKR1C3AKR1C2PTGER4CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092561-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | GLAXO GROUP LIMITED (GB) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092561-A1 | BENZOISOINDOLE DERIVATIVES FOR THE TREATMENT OF PAIN | OPRK1, OPRD1, OPRL1 | AKR1C3 885/4885AKR1C2 1676/4885PTGER4 106/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.