SCHEMBL15915380

SCHEMBL15915380

Cc1ccc(-c2cc(C(F)(F)F)nn2-c2ccccc2)cc1.N[SH](=O)=O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGS1 P23219 6/20 0.68
PTGS2 P35354 9/20 0.67
PDPK1 O15530 5/20 0.67
CYP2C9 P11712 3/20 0.67
HDAC3 O15379 2/20 0.67
ALOX5 P09917 2/20 0.67
HDAC4 P56524 2/20 0.67
HDAC1 Q13547 2/20 0.67
HDAC7 Q8WUI4 2/20 0.67
HDAC2 Q92769 2/20 0.67
HDAC10 Q969S8 2/20 0.67
HDAC11 Q96DB2 2/20 0.67
HDAC8 Q9BY41 2/20 0.67
HDAC6 Q9UBN7 2/20 0.67
HDAC9 Q9UKV0 2/20 0.67
HDAC5 Q9UQL6 2/20 0.67
PTGES O14684 1/20 0.67
CA12 O43570 1/20 0.67
PDE5A O76074 1/20 0.67
ABCB11 O95342 1/20 0.67

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5344449 0.92 PTGS1 (0.80) PTGS1PTGS2PDPK1CYP2C9HDAC3
SCHEMBL22288994 0.91 PTGS1 (0.78) PTGS1PTGS2PDPK1CYP2C9MAPT
Carbamic Acid SCHEMBL5859288 0.90 PTGS1 (0.68) PTGS1PTGS2PDPK1CYP2C9HDAC3
Sulfamide SCHEMBL7136410 0.90 PTGS2 (0.78) PTGS1PTGS2PDPK1CYP2C9HDAC3
SCHEMBL22289007 0.89 PTGS1 (0.70) PTGS1PTGS2PDPK1CYP2C9MAPT
SCHEMBL22289092 0.88 PTGS1 (0.68) PTGS1PTGS2PDPK1CYP2C9MAPT
SCHEMBL22289089 0.88 PTGS2 (0.73) PTGS1PTGS2PDPK1CYP2C9CYP3A4
SCHEMBL22288584 0.87 PTGS2 (0.75) PTGS1PTGS2PDPK1CYP2C9CYP3A4
SCHEMBL14198881 0.87 PTGS1 (0.80) PTGS1PTGS2PDPK1CYP2C9HDAC3
SCHEMBL15252012 0.86 PTGS2 (0.71) PTGS1PTGS2PDPK1CYP2C9CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3917908-A1 A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF Council of Scientific & Industrial Research (IN) 2021-12-08 EP claimed
WO-2020157771-A1 A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2020-08-06 WO claimed
EP-3917908-B1 A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF COUNCIL SCIENT IND RES (IN) 2024-08-14 EP disclosed
EP-3917908-A1 A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF Council of Scientific & Industrial Research (IN) 2021-12-08 EP disclosed
WO-2020157771-A1 A CONTINUOUS FLOW MICRO-TOTAL PROCESS SYSTEM FOR PREPARATION OF CELECOXIB AND ANALOGS THEREOF COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) 2020-08-06 WO disclosed
US-20140220040-A1 ANTIBODIES TO LRP6 ARCA BIOPHARMA, INC. (US) 2014-08-07 US disclosed