Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 15/20 | 0.63 |
| ▸ | FEN1 | P39748 | 14/20 | 0.59 |
| ▸ | F2 | P00734 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 2/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.42 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15918040 | 0.77 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL15918296 | 0.75 | ALOX5AP (0.61) | ALOX5APFEN1F2F10PRSS1 | |
| SCHEMBL15916448 | 0.74 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL15918295 | 0.74 | ALOX5AP (0.67) | ALOX5APFEN1PRMT5WDR77 | |
| SCHEMBL17367693 | 0.73 | ALOX5AP (0.80) | ALOX5APFEN1F2F10PRSS1 | |
| SCHEMBL7265195 | 0.69 | ALOX5AP (0.56) | ALOX5APFEN1F2F10PRSS1 | |
| SCHEMBL20627348 | 0.67 | ALOX5AP (0.68) | ALOX5APFEN1PRMT5WDR77AXL | |
| SCHEMBL17367667 | 0.67 | FEN1 (1.00) | ALOX5APFEN1F2F10PRSS1 | |
| SCHEMBL15917577 | 0.66 | ALOX5AP (1.00) | ALOX5APFEN1 | |
| SCHEMBL20627333 | 0.66 | ALOX5AP (0.68) | ALOX5APFEN1AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9079866-B2 | Flap modulators | JANSSEN PHARMACEUTICA NV (BE) | 2015-07-14 | — | — | US | disclosed |
| US-20140221311-A1 | FLAP MODULATORS | JANSSEN PHARMACEUTICA NV (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140221311-A1 | FLAP MODULATORS | PGF, FEN1, TBXA2R | ALOX5AP 80/4885FEN1 2/4885F2 142/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.