Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Monoethanolamine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.43 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | FPR3 | P25089 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.41 |
| ▸ | OGA | O60502 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3614438 | 0.94 | HSD11B1 (0.56) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL15649538 | 0.82 | HSD11B1 (0.54) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL29112390 | 0.72 | HSD11B1 (0.54) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL24540861 | 0.72 | HSD11B1 (0.54) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL29112392 | 0.72 | HSD11B1 (0.54) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL29141636 | 0.71 | HSD11B1 (0.52) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL10558453 | 0.69 | HTT (0.62) | TAS1R3TAS1R1ALDH1A1HTTATM | |
| SCHEMBL10311684 | 0.68 | HTT (0.64) | HSD11B1TAS1R3TAS1R1ALDH1A1HTT | |
| SCHEMBL20930005 | 0.68 | HSD11B1 (0.48) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR | |
| SCHEMBL20930285 | 0.68 | HSD11B1 (0.48) | HSD11B1TAS1R3TAS1R1ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9023776-B2 | Rinse-off compositions comprising lactoyl ethanolamine and a menthanecarboxamide compound | GIVAUDAN S.A. (CH) | 2015-05-05 | — | — | US | disclosed |
| US-20140221265-A1 | RINSE-OFF COMPOSITIONS | GIVAUDAN S.A. (CH) | 2014-08-07 | — | — | US | disclosed |