Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13450960 | 0.77 | KMT2A (0.52) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL4503439 | 0.77 | ATM (0.48) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL14538084 | 0.77 | ATM (0.48) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL1220310 | 0.77 | KMT2A (0.52) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL429744 | 0.75 | ATM (0.56) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL9040661 | 0.75 | ATM (0.56) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL20729443 | 0.75 | CA12 (0.43) | POLBMAPTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL944668 | 0.74 | ALDH1A1 (0.53) | ATMHPGDRAB9AMAPTMEN1 | |
| SCHEMBL13039605 | 0.74 | ATM (0.50) | ATMHPGDRAB9APOLBMAPT | |
| SCHEMBL31007038 | 0.74 | ALDH1A1 (0.59) | ATMHPGDRAB9APOLBMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014113932-A1 | BTK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-07-31 | — | — | WO | disclosed |