Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | AGO2 | Q9UKV8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15901038 | 0.76 | ATF1 (0.32) | — | |
| SCHEMBL26538070 | 0.75 | MAPT (0.41) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL20355508 | 0.73 | POLB (0.38) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL12883359 | 0.70 | POLB (0.43) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL21016979 | 0.68 | POLB (0.41) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL16302668 | 0.68 | PDE4A (0.57) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL12010925 | 0.67 | PDE4A (0.53) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL17700671 | 0.63 | NUDT1 (0.42) | PDE4AAGO2ALDH1A1KDM4ELMNA | |
| SCHEMBL20605048 | 0.61 | HTT (0.41) | ALDH1A1KDM4ELMNAUSP2POLB | |
| SCHEMBL1312907 | 0.61 | CA2 (0.36) | ALDH1A1KDM4ELMNAUSP2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014114694-A1 | 2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-07-31 | — | — | WO | disclosed |