SCHEMBL15920701

SCHEMBL15920701

CNC(=O)c1ccc(C#N)c(C)c1

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
S1PR3 Q99500 19/20 0.58
S1PR1 P21453 10/20 0.48
S1PR4 O95977 2/20 0.48
S1PR2 O95136 1/20 0.48
AR P10275 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3817006 0.86 VNN1 (0.45) S1PR3AR
SCHEMBL18957967 0.83 HDAC6 (0.44) S1PR3
SCHEMBL22099996 0.82 S1PR3 (0.54) S1PR3S1PR1S1PR4S1PR2AR
SCHEMBL15955802 0.82 S1PR3 (0.54) S1PR3S1PR1S1PR4S1PR2AR
SCHEMBL20633537 0.81 PLAU (0.45) S1PR3AR
SCHEMBL20787390 0.81 S1PR3 (0.59) S1PR3S1PR1S1PR4S1PR2AR
SCHEMBL12670890 0.81 S1PR3 (0.57) S1PR3S1PR1S1PR4S1PR2
SCHEMBL20787536 0.81 HDAC8 (0.47) S1PR3S1PR1AR
SCHEMBL996704 0.80 MRGPRX4 (0.56) S1PR3
SCHEMBL2369495 0.80 S1PR3 (0.51) S1PR3S1PR1S1PR4S1PR2AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230406851-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2023-12-21 US disclosed
EP-3998267-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF Bellus Health Cough Inc. (CA) 2022-05-18 EP disclosed
US-20220062290-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2022-03-03 US disclosed
US-20220062290-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2022-03-03 US disclosed
EP-3381917-B1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF BELLUS HEALTH COUGH INC (CA) 2021-09-08 EP disclosed
US-20210228588-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2021-07-29 US disclosed
US-20210228588-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2021-07-29 US disclosed
US-20200390779-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2020-12-17 US disclosed
US-20200390779-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2020-12-17 US disclosed
US-20200138826-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2020-05-07 US disclosed
US-9814725-B2 Imidazopyridine compounds and uses thereof NEOMED INSTITUTE (CA) 2017-11-14 US disclosed
US-20170143730-A1 Imidazopyridine Compounds and Uses Thereof GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2017-05-25 US disclosed
US-20170143730-A1 Imidazopyridine Compounds and Uses Thereof GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2017-05-25 US disclosed
US-9598409-B2 Imidazopyridine compounds and uses thereof NEOMED INSTITUTE (CA) 2017-03-21 US disclosed
US-9598409-B2 Imidazopyridine compounds and uses thereof NEOMED INSTITUTE (CA) 2017-03-21 US disclosed
US-20150361078-A1 Imidazopyridine Compounds and Uses Thereof GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2015-12-17 US disclosed
US-20150361078-A1 Imidazopyridine Compounds and Uses Thereof GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.3) LIMITED (GB) 2015-12-17 US disclosed
EP-2951177-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF Neomed Institute (CA) 2015-12-09 EP disclosed
WO-2014117274-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NEOMED INSTITUTE (CA) 2014-08-07 WO disclosed
WO-2014117274-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NEOMED INSTITUTE (CA) 2014-08-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230406851-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885
US-20200390779-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885
US-20150361078-A1 Imidazopyridine Compounds and Uses Thereof NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885
US-20220062290-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885
US-20200138826-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885
US-20170143730-A1 Imidazopyridine Compounds and Uses Thereof NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885
US-20210228588-A1 IMIDAZOPYRIDINE COMPOUNDS AND USES THEREOF NISCH, ABL1, PAICS S1PR3 1929/4885S1PR1 2439/4885S1PR4 1517/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.