Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERN1 | O75460 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | RXRA | P19793 | 1/20 | 0.49 |
| ▸ | RXRB | P28702 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 4/20 | 0.46 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | CA12 | O43570 | 3/20 | 0.46 |
| ▸ | CA9 | Q16790 | 3/20 | 0.46 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23226759 | 0.89 | RXRA (0.61) | ERN1MAPTMEN1KMT2ACASP3 | |
| SCHEMBL15920879 | 0.82 | APP (0.46) | ERN1MAPTMEN1KMT2ACASP3 | |
| SCHEMBL30642568 | 0.80 | MEN1 (0.50) | MAPTMEN1KMT2ACASP3SENP7 | |
| SCHEMBL2823344 | 0.80 | MEN1 (0.50) | MAPTMEN1KMT2ACASP3SENP7 | |
| SCHEMBL14926631 | 0.79 | CA1 (0.58) | MAPTCA1CA2NPC1RAB9A | |
| SCHEMBL2952068 | 0.79 | MEN1 (0.68) | ERN1MAPTMEN1KMT2ACA1 | |
| SCHEMBL15920894 | 0.79 | MAPT (0.65) | ERN1MAPTMEN1KMT2ACASP3 | |
| SCHEMBL10009170 | 0.79 | CA1 (0.61) | ERN1MAPTMEN1KMT2ACA1 | |
| SCHEMBL16749645 | 0.79 | CA1 (0.61) | ERN1MAPTMEN1KMT2ACA1 | |
| SCHEMBL15920786 | 0.78 | NOTUM (0.49) | MAPTMEN1KMT2ACASP3SENP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2943474-B1 | BIARYL- OR HETEROCYCLIC BIARYL-SUBSTITUTED CYCLOHEXENE DERIVATIVE COMPOUNDS AS CETP INHIBITORS | CHONG KUN DANG PHARMACEUTICAL CORP (KR) | 2017-07-05 | — | — | EP | disclosed |
| US-9493430-B2 | Biaryl- or heterocyclic biaryl-substituted cyclohexene derivative compounds as CETP inhibitors | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2016-11-15 | — | — | US | disclosed |
| US-20160237046-A9 | Biaryl- or Heterocyclic Biaryl-Substituted Cyclohexene Derivative Compounds as CETP Inhibitors | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2016-08-18 | — | — | US | disclosed |
| EP-2943474-A1 | BIARYL- OR HETEROCYCLIC BIARYL-SUBSTITUTED CYCLOHEXENE DERIVATIVE COMPOUNDS AS CETP INHIBITORS | Chong Kun Dang Pharmaceutical Corp. (KR) | 2015-11-18 | — | — | EP | disclosed |
| US-20150322023-A1 | Biaryl- or Heterocyclic Biaryl-Substituted Cyclohexene Derivative Compounds as CETP Inhibitors | CHONG KUN DANG PHARM CORP (KR) | 2015-11-12 | — | — | US | disclosed |
| WO-2014119947-A1 | BIARYL- OR HETEROCYCLIC BIARYL-SUBSTITUTED CYCLOHEXENE DERIVATIVE COMPOUNDS AS CETP INHIBITORS | CHONG KUN DANG PHARMACEUTICAL CORP. (KR) | 2014-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160237046-A9 | Biaryl- or Heterocyclic Biaryl-Substituted Cyclohexene Derivative Compounds as CETP Inhibitors | CETP, LIPC, PCSK9 | ERN1 1925/4885MAPT 3024/4885MEN1 4541/4885 |
| US-20150322023-A1 | Biaryl- or Heterocyclic Biaryl-Substituted Cyclohexene Derivative Compounds as CETP Inhibitors | CETP, LIPC, PCSK9 | ERN1 1925/4885MAPT 3024/4885MEN1 4541/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.