Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.40 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 3/20 | 0.35 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1590863 | 0.75 | NPC1 (0.50) | CYP2D6CYP2C9TSHRCYP2C19YTHDC1 | |
| SCHEMBL22587406 | 0.70 | CYP2D6 (0.55) | CYP2D6CYP2C9TSHRCYP2C19YTHDC1 | |
| SCHEMBL5194070 | 0.68 | FLT3 (0.64) | NPC1CDK2FLT3PDGFRASRC | |
| SCHEMBL8846952 | 0.68 | CHRNB2 (0.49) | CYP2C19 | |
| SCHEMBL8846954 | 0.68 | CHRNB2 (0.49) | CYP2C19 | |
| SCHEMBL4019471 | 0.68 | CHRNB2 (0.49) | CYP2C19 | |
| SCHEMBL4565107 | 0.67 | EGFR (0.38) | CDK2CCNA2FLT3PDGFRASRC | |
| SCHEMBL30677365 | 0.67 | CYP2D6 (0.65) | CYP2D6CYP2C9TSHRCYP2C19YTHDC1 | |
| SCHEMBL27388299 | 0.67 | YTHDC1 (0.70) | CYP2D6CYP2C9TSHRCYP2C19YTHDC1 | |
| SCHEMBL5195445 | 0.67 | SCTR (0.63) | NPC1CDK2FLT3PDGFRASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110092491-A1 | Compounds and Compositions as Inhibitors of Receptor Tyrosine Kinase Activity | NOVARTIS AG (CH) | 2011-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110092491-A1 | Compounds and Compositions as Inhibitors of Receptor Tyrosine Kinase Activity | BMX, LCK, FYN | CYP2D6 4705/4885CYP2C9 4457/4885TSHR 999/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.