Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | SLC1A2 | P43004 | 6/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | THPO | P40225 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16326618 | 1.00 | PKM (0.43) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL31289285 | 1.00 | PKM (0.43) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL27788944 | 1.00 | PKM (0.43) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL1592240 | 1.00 | PKM (0.43) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL28063284 | 1.00 | PKM (0.43) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL25225659 | 0.98 | PKM (0.42) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| Hydrochloric Acid SCHEMBL4300372 | 0.98 | PKM (0.42) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL28732867 | 0.98 | PKM (0.42) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| Lithium SCHEMBL29718901 | 0.98 | PKM (0.42) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 | |
| SCHEMBL30703914 | 0.98 | PKM (0.42) | PKMSLC1A2CYP1A2ALDH1A1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 147 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114605310-B | Synthesis method of aza five-membered ring and three-membered ring carboxylic ester derivative and salt thereof | 都创(上海)医药科技股份有限公司 | 2024-05-07 | — | — | CN | claimed |
| CN-114539125-B | Synthesis method of paciclovir intermediate | 杭州国瑞生物科技有限公司 | 2024-02-09 | — | — | CN | claimed |
| WO-2023168827-A1 | SYNTHESIS METHOD FOR PAXLOVID INTERMEDIATE | 杭州国瑞生物科技有限公司 | 2023-09-14 | — | — | WO | claimed |
| WO-2023151188-A1 | GREEN SYNTHESIS METHOD OF ANTIVIRAL DRUG INTERMEDIATE | 上海皓元医药股份有限公司 | 2023-08-17 | — | — | WO | claimed |
| CN-114394927-B | Process for the preparation of 6, 6-dimethyl-3-azabicyclo [3.1.0] hexane-2-carboxylic acid | 汉瑞药业(荆门)有限公司 | 2023-03-31 | — | — | CN | claimed |
| CN-115109760-A | Monoamine oxidase and application thereof in preparation of pharmaceutical intermediate | 弈柯莱生物科技(上海)股份有限公司 | 2022-09-27 | — | — | CN | claimed |
| CN-114958938-A | Preparation method of fused bicyclic proline methyl ester hydrochloride | 金达威生物技术(江苏)有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-114671798-B | Green synthesis method of antiviral drug intermediate | 上海皓元医药股份有限公司 | 2022-08-16 | — | — | CN | claimed |
| CN-114671798-A | Green synthesis method of antiviral drug intermediate | 上海皓元医药股份有限公司 | 2022-06-28 | — | — | CN | claimed |
| CN-114605310-A | Synthesis method of aza five-membered ring and three-membered ring carboxylate derivative and salt thereof | 都创(上海)医药科技股份有限公司 | 2022-06-10 | — | — | CN | claimed |
| CN-114539125-A | Synthetic method of pasiclovir intermediate | 杭州国瑞生物科技有限公司 | 2022-05-27 | — | — | CN | claimed |
| CN-114456101-A | Synthesis method of key intermediate for synthesizing PF-07321332 | 上海璨谊生物科技有限公司 | 2022-05-10 | — | — | CN | claimed |
| CN-114394927-A | Process for preparing 6, 6-dimethyl-3-azabicyclo [3.1.0] hexane-2-carboxylic acid | 汉瑞药业(荆门)有限公司 | 2022-04-26 | — | — | CN | claimed |
| CN-114031543-A | Preparation method of intermediate of palovaried | 上海朴颐化学科技有限公司 | 2022-02-11 | — | — | CN | claimed |
| US-12365706-B2 | Macrocyclic peptides as potent inhibitors of K-RAS G12D mutant | MERCK SHARP & DOHME LLC (US) | 2025-07-22 | — | — | US | disclosed |
| CN-119677728-A | Process and intermediates for the preparation of nemaltevir | 辉瑞大药厂 | 2025-03-21 | — | — | CN | disclosed |
| US-20250059171-A1 | ANTIVIRAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 2025-02-20 | — | — | US | disclosed |
| CN-1805931-A | Processes and intermediates for preparing (1R,2S,5S) -6, 6-dimethyl-3-azabicyclo [3,1,0] hexane-2-carboxylate or salts thereof | SCHERING CORP (US) | 2006-07-19 | — | — | CN | disclosed |
| US-20050059648-A1 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | SCHERING CORPORATION | 2005-03-17 | — | — | US | disclosed |
| US-20050059648-A1 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | SCHERING CORPORATION | 2005-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12365706-B2 | Macrocyclic peptides as potent inhibitors of K-RAS G12D mutant | KRAS, NRAS, HRAS | PKM 2452/4885SLC1A2 4343/4885CYP1A2 4508/4885 |
| US-20050059648-A1 | Process and intermediates for the preparation of (1R,2S,5S)-6,6-dimethyl-3-azabicyclo[3,1,0]hexane-2-carboxylates or salts thereof | AZI2, MED1, ALKBH5 | PKM 2170/4885SLC1A2 4152/4885CYP1A2 104/4885 |
| US-20250059171-A1 | ANTIVIRAL COMPOUNDS | ZC3HAV1, ACE, EIF2AK2 | PKM 1850/4885SLC1A2 4727/4885CYP1A2 773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.