Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.63 |
| ▸ | HPGD | P15428 | 5/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 8/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PDE9A | O76083 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7271706 | 0.77 | ALDH1A1 (1.00) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL16935203 | 0.76 | ALDH1A1 (0.96) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL9846227 | 0.74 | ALDH1A1 (0.93) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL16935255 | 0.71 | ALDH1A1 (0.60) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL16935340 | 0.70 | ALDH1A1 (0.58) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL29740984 | 0.70 | ALDH1A1 (0.70) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL16935293 | 0.70 | ALDH1A1 (0.61) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL23782955 | 0.68 | PDE9A (0.61) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL28922159 | 0.68 | KDM4E (0.46) | ALDH1A1KDM4EHPGDKMT2AHIF1A | |
| SCHEMBL16935353 | 0.68 | ALDH1A1 (0.56) | ALDH1A1KDM4EHPGDKMT2AHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10059671-B2 | Positive allosteric modulators of mGluR3 | PREXTON THERAPEUTICS SA (CH) | 2018-08-28 | — | — | US | disclosed |
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2015-12-17 | — | — | US | disclosed |
| EP-2951157-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | Merck Patent GmbH (DE) | 2015-12-09 | — | — | EP | disclosed |
| WO-2014117919-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2014-08-07 | — | — | WO | disclosed |
| WO-2014117919-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | MERCK PATENT GMBH (DE) | 2014-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150361046-A1 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR3 | GRM3, GRM1, GRM4 | ALDH1A1 4723/4885KDM4E 1126/4885HPGD 3834/4885 |
| US-10059671-B2 | Positive allosteric modulators of mGluR3 | GRM3, GRM1, GRM4 | ALDH1A1 4723/4885KDM4E 1126/4885HPGD 3834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.