Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.72 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.71 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.71 |
| ▸ | RAB9A | P51151 | 8/20 | 0.68 |
| ▸ | NPC1 | O15118 | 7/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.60 |
| ▸ | PKM | P14618 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | METTL3 | Q86U44 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4620787 | 0.84 | MAPT (1.00) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| SCHEMBL118449 | 0.83 | PTGS1 (1.00) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| SCHEMBL2334973 | 0.81 | PTGS1 (0.96) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| Hydrochloric Acid SCHEMBL8878519 | 0.81 | PTGS1 (0.96) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| Water SCHEMBL21708935 | 0.81 | PTGS1 (0.96) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| SCHEMBL7929884 | 0.81 | PTGS1 (0.72) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| Bromide SCHEMBL570786 | 0.81 | PTGS1 (0.96) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| SCHEMBL2468923 | 0.81 | RAB9A (1.00) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| SCHEMBL31040086 | 0.81 | MAPT (0.68) | MAPTCYP1A2CYP3A4PTGS1PTGS2 | |
| SCHEMBL1583201 | 0.81 | PTGS1 (0.66) | MAPTCYP1A2CYP3A4PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115551864-A | Substituted tricyclic amides, analogs thereof, and methods of using the same | 爱彼特生物制药公司 | 2022-12-30 | — | — | CN | disclosed |
| WO-2017075694-A1 | ANTIBIOTIC COMPOUNDS, PHARMACEUTICAL FORMULATIONS THEREOF AND METHODS AND USES THEREFOR | SIMON FRASER UNIVERSITY (CA) | 2017-05-11 | — | — | WO | disclosed |
| WO-2015017407-A1 | BRIDGED BICYCLIC AMINO THIAZINE DIOXIDE COMPOUNDS AS INHIBITORS OF BETA- SECRETASE | AMGEN INC. (US) | 2015-02-05 | — | — | WO | disclosed |
| WO-2014120658-A1 | FUSED MULTICYCLIC 3-AMINO-5,6-DIHYDRO-2H-1,4-THIAZINE DERIVATIVES AND THEIR USE AS BETA-SECRETASE INHIBITORS | AMGEN INC. (US) | 2014-08-07 | — | — | WO | disclosed |
| WO-2014059185-A1 | AMINO - DIHYDROTHIAZINE AND AMINO - DIOXIDO DIHYDROTHIAZINE COMPOUNDS AS BETA-SECRETASE ANTAGONISTS AND METHODS OF USE | AMGEN INC. (US) | 2014-04-17 | — | — | WO | disclosed |