Sugi Predict

Sugi Predict / Compounds / Bromide

Bromide

Bromide

SCHEMBL570786

Br.O=C(O)c1cn2ccccc2n1

nearest known ligand 0.96

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ PTGS1 P23219 2/20 0.96
▸ PTGS2 P35354 2/20 0.96
▸ RAB9A P51151 7/20 0.65
▸ NPC1 O15118 6/20 0.65
▸ MAPT P10636 4/20 0.64
▸ CYP1A2 P05177 1/20 0.64
▸ CYP3A4 P08684 1/20 0.64
▸ TP53 P04637 1/20 0.52
▸ KDM4E B2RXH2 7/20 0.51
▸ PKM P14618 2/20 0.51
▸ SMN1; SMN2 Q16637 3/20 0.50
▸ ALDH1A1 P00352 2/20 0.50
▸ HPGD P15428 1/20 0.50
▸ POLB P06746 1/20 0.50
▸ GFER P55789 1/20 0.49
▸ HDAC4 P56524 1/20 0.46
▸ DRD2 P14416 1/20 0.45
▸ DRD3 P35462 1/20 0.45
▸ METTL3 Q86U44 1/20 0.45
▸ RBP4 P02753 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL118449 0.98 PTGS1 (1.00) PTGS1PTGS2RAB9ANPC1MAPT
Water SCHEMBL21708935 0.96 PTGS1 (0.96) PTGS1PTGS2RAB9ANPC1MAPT
Hydrochloric Acid SCHEMBL8878519 0.96 PTGS1 (0.96) PTGS1PTGS2RAB9ANPC1MAPT
SCHEMBL2334973 0.96 PTGS1 (0.96) PTGS1PTGS2RAB9ANPC1MAPT
SCHEMBL1728538 0.83 PTGS1 (0.73) PTGS1PTGS2RAB9ANPC1MAPT
SCHEMBL7929884 0.82 PTGS1 (0.72) PTGS1PTGS2RAB9ANPC1MAPT
SCHEMBL174711 0.82 PTGS1 (0.72) PTGS1PTGS2RAB9ANPC1MAPT
SCHEMBL2524283 0.82 PTGS1 (0.72) PTGS1PTGS2RAB9ANPC1MAPT
SCHEMBL15924280 0.81 MAPT (0.72) PTGS1PTGS2RAB9ANPC1MAPT
Lithium Ion SCHEMBL2334977 0.81 PTGS1 (0.70) PTGS1PTGS2RAB9ANPC1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20170152288-A1 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY NOVALIX DEUTSCHLAND GMBH (DE) 2017-06-01 — — US disclosed
EP-2601208-B1 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY GRAFFINITY PHARMACEUTICALS GMBH (DE) 2015-02-11 — — EP disclosed
EP-2601208-A2 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY Graffinity Pharmaceuticals GmbH (DE) 2013-06-12 — — EP disclosed
US-20130131321-A1 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY GRAFFINITY PHARMACEUTICALS GMBH (DE) 2013-05-23 — — US disclosed
WO-2012017021-A2 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY GRAFFINITY PHARMACEUTICALS GMBH (DE) 2012-02-09 — — WO disclosed
US-20090035313-A1 Compounds PFIZER INC. 2009-02-05 — — US disclosed
EP-1651641-B1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS PFIZER LTD (GB) 2007-05-23 — — EP disclosed
EP-1651640-B1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS PFIZER LTD (GB) 2007-02-14 — — EP disclosed
US-7153870-B2 Nicotinamide derivatives useful as PDE4 inhibitors PFIZER INC. (US) 2006-12-26 — — US disclosed
US-20060178408-A1 Nicotinamide derivatives useful as pde4 inhibitors BARBER CHRISTOPHER G 2006-08-10 — — US disclosed
EP-1651640-A1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS Pfizer Limited (GB) 2006-05-03 — — EP disclosed
US-20050043326-A1 Compounds PFIZER INC 2005-02-24 — — US disclosed
WO-2005009994-A1 NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS PFIZER LIMITED (GB) 2005-02-03 — — WO disclosed
US-20050020611-A1 Compounds PFIZER INC. 2005-01-27 — — US disclosed
US-20050020626-A1 Nicotinamide derivatives useful as PDE4 inhibitors PFIZER INC 2005-01-27 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050020611-A1 Compounds NQO1, NAMPT, NNT PTGS1 889/4885PTGS2 1093/4885RAB9A 1644/4885
US-20050020626-A1 Nicotinamide derivatives useful as PDE4 inhibitors PDE4A, PDE4B, PDE4C PTGS1 451/4885PTGS2 877/4885RAB9A 1528/4885
US-20060178408-A1 Nicotinamide derivatives useful as pde4 inhibitors PDE4A, PDE4B, PDE4C PTGS1 609/4885PTGS2 1068/4885RAB9A 1303/4885
US-20170152288-A1 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY FCGR1A, FCGR2A, FCGR3B PTGS1 3730/4885PTGS2 3687/4885RAB9A 3306/4885
US-20090035313-A1 Compounds NQO1, NAMPT, NNT PTGS1 889/4885PTGS2 1093/4885RAB9A 1644/4885
US-20130131321-A1 LIGANDS FOR ANTIBODY AND Fc-FUSION PROTEIN PURIFICATION BY AFFINITY CHROMATOGRAPHY FCGR1A, FCGR2A, FCER2 PTGS1 3399/4885PTGS2 4006/4885RAB9A 3980/4885
US-20050043326-A1 Compounds NQO1, NAMPT, NNT PTGS1 889/4885PTGS2 1093/4885RAB9A 1644/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.