Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 1/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15925466 | 0.98 | CETP (0.49) | CETPAPPARPPARGPPARA | |
| SCHEMBL15925458 | 0.89 | CETP (0.58) | CETPAPPARPPARGPPARA | |
| SCHEMBL15925455 | 0.88 | AR (0.52) | CETPARPPARGPPARAALDH1A1 | |
| SCHEMBL10288616 | 0.86 | PIK3CD (0.48) | CETPAPPKDM4EALDH1A1GAA | |
| SCHEMBL15925474 | 0.85 | SMN1; SMN2 (0.49) | ARPPARGPPARAALDH1A1HPGD | |
| SCHEMBL10298737 | 0.84 | CETP (0.49) | CETPAPPKDM4EALDH1A1HPGD | |
| SCHEMBL15925464 | 0.84 | SMN1; SMN2 (0.50) | CETPARPPARGPPARAALDH1A1 | |
| SCHEMBL10288310 | 0.83 | PIK3CD (0.50) | CETPAPPKDM4EALDH1A1GAA | |
| SCHEMBL15925468 | 0.83 | AR (0.44) | CETPARPPARGPPARAALDH1A1 | |
| SCHEMBL15925488 | 0.83 | AR (0.44) | CETPARPPARGPPARAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796268-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |