Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.43 |
| ▸ | PIK3C3 | Q8NEB9 | 11/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.36 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.36 |
| ▸ | FPR2 | P25090 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | AHR | P35869 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15925740 | 0.90 | CDC7 (0.40) | CDC7DBF4PIK3C3TGFBR1TGFBR2 | |
| SCHEMBL15925751 | 0.90 | CDC7 (0.40) | CDC7DBF4PIK3C3TGFBR1TGFBR2 | |
| SCHEMBL10288807 | 0.89 | CDC7 (0.42) | CDC7DBF4PIK3C3TGFBR1TGFBR2 | |
| SCHEMBL15925761 | 0.87 | CDC7 (0.41) | CDC7DBF4PIK3C3TGFBR1TGFBR2 | |
| SCHEMBL15925767 | 0.86 | CDC7 (0.39) | CDC7DBF4PIK3C3TGFBR1TGFBR2 | |
| SCHEMBL15925705 | 0.84 | MAPK1 (0.35) | FFAR2MAPK14 | |
| SCHEMBL15925723 | 0.84 | MAPK1 (0.35) | FFAR2MAPK14 | |
| SCHEMBL15925728 | 0.84 | MAPK1 (0.35) | FFAR2MAPK14 | |
| SCHEMBL15925694 | 0.84 | IDO1 (0.32) | FFAR2 | |
| SCHEMBL15925713 | 0.84 | IDO1 (0.32) | FFAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796271-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2014-08-05 | — | — | US | disclosed |