Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.35 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26468519 | 0.85 | CHRNB2 (0.34) | CHRNB2CHRNA4CHRNB4CHRNA3SPHK1 | |
| SCHEMBL209164 | 0.83 | SPHK1 (0.50) | SPHK1SMN1; SMN2 | |
| SCHEMBL222670 | 0.83 | SPHK1 (0.50) | SPHK1SMN1; SMN2 | |
| SCHEMBL15257477 | 0.83 | SPHK1 (0.32) | SPHK1TSHRSMN1; SMN2 | |
| SCHEMBL222671 | 0.83 | SPHK1 (0.50) | SPHK1SMN1; SMN2 | |
| SCHEMBL15925932 | 0.82 | SPHK1 (0.32) | CHRNB2CHRNA4CHRNB4CHRNA3SPHK1 | |
| SCHEMBL1503804 | 0.81 | CYP1A2 (0.31) | SPHK1 | |
| SCHEMBL158240 | 0.81 | CYP1A2 (0.31) | SPHK1 | |
| SCHEMBL5018437 | 0.79 | SPHK1 (0.30) | SPHK1 | |
| SCHEMBL8085510 | 0.75 | HTR2C (0.51) | SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1137085-C | Process for preparation of 5,6-dihydroxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | ������˹ҩƷ��˾ | 2004-02-04 | — | — | CN | disclosed |
| CN-1073984-C | Process for preparing 5, 6-dihydroxy-2-amino-1, 2,3, 4-tetrahydronaphthalene derivatives | CHIESI FARMA SPA (IT) | 2001-10-31 | — | — | CN | disclosed |
| CN-1278527-A | Process for preparation of 5,6-dihydrxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI PHARMACEUTICAL S P A (IT) | 2001-01-03 | — | — | CN | disclosed |
| CN-1278528-A | Process for preparation of 5,6-dihydroxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI PHARMACEUTICAL S P A (IT) | 2001-01-03 | — | — | CN | disclosed |
| CN-1278526-A | Process for preparation of 5,6-dihydroxyl-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI PHARMACEUTICAL S P A (IT) | 2001-01-03 | — | — | CN | disclosed |
| EP-0788472-B1 | A PROCESS FOR THE PREPARATION OF 5,6-DIHYDROXY-2-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | CHIESI FARMA SPA (IT) | 2000-08-02 | — | — | EP | disclosed |
| US-6034277-A | Process for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 2000-03-07 | — | — | US | disclosed |
| US-5936125-A | Process for the preparation of 5,6-dihydroxy-2-amino-1,2,3,4-tetrahydronaphthalene derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 1999-08-10 | — | — | US | disclosed |
| US-5710336-A | Process for the preparation of 5-6-dihydroxy-2-amino-1, 2, 3, 4-tetrahydronaphthalene derivatives | CHIESI FARMACEUTICI S.P.A. (IT) | 1998-01-20 | — | — | US | disclosed |
| CN-1147808-A | Process for preparing 5, 6-dihydroxy-2-amino-1, 2, 3, 4-tetrahydronaphthalene derivatives | CHIESI FARMA SPA (IT) | 1997-04-16 | — | — | CN | disclosed |