Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2644689 | 0.77 | MAPT (0.43) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2643618 | 0.74 | MAPT (0.40) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL27746396 | 0.74 | ALDH1A1 (0.43) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2643582 | 0.74 | MAPT (0.40) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2644105 | 0.74 | MAPT (0.46) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2643774 | 0.74 | KDM4E (0.47) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2643961 | 0.73 | HTT (0.46) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL2663945 | 0.73 | MAPT (0.35) | MAPTALDH1A1KDM4ESIGMAR1POLB | |
| SCHEMBL2644848 | 0.73 | MAPT (0.37) | MAPTALDH1A1KDM4ESIGMAR1CYP1A2 | |
| SCHEMBL2644069 | 0.72 | DRD4 (0.35) | MAPTALDH1A1KDM4ESIGMAR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796313-B2 | Substituted dihydroisoindolones as allosteric modulators of glucokinase | JANSSEN PHARMACEUTICA N.V. (BE) | 2014-08-05 | — | — | US | disclosed |