Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ARF6 | P62330 | 1/20 | 0.35 |
| ▸ | KCNQ3 | O43525 | 1/20 | 0.34 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.34 |
| ▸ | PDE2A | O00408 | 2/20 | 0.33 |
| ▸ | TP53 | P04637 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | BCL9 | O00512 | 1/20 | 0.33 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15926362 | 0.87 | AR (0.37) | ARF6KCNQ3KCNQ2PDE2A | |
| SCHEMBL1613995 | 0.84 | PDE2A (0.34) | MAPTKMT2APDE2ATP53LMNA | |
| SCHEMBL15926318 | 0.81 | MAPK14 (0.32) | MAPTARF6KCNQ3KCNQ2 | |
| SCHEMBL15926333 | 0.80 | MAPT (0.41) | MAPTARF6KCNQ3KCNQ2TP53 | |
| SCHEMBL1613466 | 0.79 | AR (0.40) | MAPTARF6PDE2ASMN1; SMN2NPC1 | |
| SCHEMBL15926314 | 0.79 | KCNQ3 (0.36) | MAPTARF6KCNQ3KCNQ2PDE2A | |
| SCHEMBL15926328 | 0.76 | MAPK14 (0.31) | MAPT | |
| SCHEMBL1614735 | 0.76 | PLAT (0.33) | MAPTKMT2AKCNQ3KCNQ2PDE2A | |
| SCHEMBL1278772 | 0.75 | MAPT (0.43) | MAPTARF6KCNQ3KCNQ2TP53 | |
| SCHEMBL1614666 | 0.74 | MAPT (0.33) | MAPTARF6KCNQ3KCNQ2GABRP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8796285-B2 | Pyrazolo [1,5-a]-pyrimidones derivatives and pharmaceutical compositions and uses thereof | HEBEI MEDICAL UNIVERSITY (CN) | 2014-08-05 | — | — | US | disclosed |