Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 5/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29658929 | 1.00 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| Aniline SCHEMBL27735093 | 0.87 | TSHR (0.44) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL31066559 | 0.81 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL3287160 | 0.81 | ALDH1A1 (0.42) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL159338 | 0.79 | TSHR (0.39) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL2505365 | 0.79 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL29435968 | 0.79 | TSHR (0.39) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL8375067 | 0.79 | ALDH1A1 (0.40) | ALDH1A1TSHRCYP3A4TDP1ALOX15 | |
| SCHEMBL31289362 | 0.77 | TNF (0.41) | TSHRTNFRIPK1IDO1TDO2 | |
| SCHEMBL2046247 | 0.77 | TNF (0.41) | TSHRTNFRIPK1IDO1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 274 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105801429-B | A kind of preparation method of the chloro- 2,4 difluorobenzene amine of 3,5- bis- | 安徽新北卡化学有限公司 | 2019-09-24 | — | — | CN | claimed |
| EP-2611797-B1 | QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS | HANMI SCIENCE CO LTD (KR) | 2016-12-28 | — | — | EP | claimed |
| CN-105801429-A | Preparation method for 3,5,-dichloro-2,4,-difluoroaniline | 上海北卡医药技术有限公司 | 2016-07-27 | — | — | CN | claimed |
| CN-103237801-B | Quinoline or quinazoline derivatives having apoptosis-inducing activity on cells | HANMI HOLDINGS Co.,Ltd. (KR) | 2015-11-25 | — | — | CN | claimed |
| US-8835458-B2 | Quinoline or quinazoline derivatives with apoptosis inducing activity on cells | HANMI SCIENCE CO., LTD (KR) | 2014-09-16 | — | — | US | claimed |
| CN-102617360-B | Synthetic method of 3, 5-dichloro-2, 4-difluoroaniline | JIANGXI JIXIANG PHARMACEUTICAL CO LTD | 2013-11-06 | — | — | CN | claimed |
| EP-2611797-A2 | QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS | Hanmi Science Co., Ltd. (KR) | 2013-07-10 | — | — | EP | claimed |
| US-20130165386-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS | HANMI SCIENCE CO., LTD (KR) | 2013-06-27 | — | — | US | claimed |
| CN-102617360-A | Synthetic method of 3, 5-dichloro-2, 4-difluoroaniline | JIANGXI JIXIANG PHARMACEUTICAL CO LTD | 2012-08-01 | — | — | CN | claimed |
| WO-2012030160-A2 | QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS | HANMI HOLDINGS CO., LTD. (KR) | 2012-03-08 | — | — | WO | claimed |
| US-20070293490-A1 | Quinazoline Derivatives | ASTRAZENECA AB (SE) | 2007-12-20 | — | — | US | claimed |
| JP-2007523072-A | — | — | 2007-08-16 | — | — | JP | claimed |
| CN-1903838-A | Preparation method of benzoyl area kind derivative | UNIV ZHEJIANG POLYTECHNIC (CN) | 2007-01-31 | — | — | CN | claimed |
| EP-1713781-A1 | QUINAZOLINE DERIVATIVES | AstraZeneca AB (SE) | 2006-10-25 | — | — | EP | claimed |
| CN-1267402-C | Synthetic method for 3,5-dichloro-2,4-difluoronitrobenzene and teflubenzuron | UNIV ZHEJIANG TECHNOLOGY (CN) | 2006-08-02 | — | — | CN | claimed |
| CN-1683318-A | Synthetic method for 3,5-dichloro-2,4-difluoronitrobenzene and teflubenzuron | UNIV ZHEJIANG POLYTECHNIC (CN) | 2005-10-19 | — | — | CN | claimed |
| WO-2005075439-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2005-08-18 | — | — | WO | claimed |
| US-6372030-B1 | INK VEHICLE SELECTED FROM 4-(HEXADECYLAMINO)BENZYLAMINE, N-OCTANOYL-N-METHYL GLUCAMINE, OCTANOIC HYDRAZIDE, 4-HEXADECYL SULFONYL ANILINE, A CONDUCTIVE COMPLEX OF AN AMINE COMPOUND WITH A PHOSPHORUS OR SULFUR-CONTAINING ACID | XEROX CORPORATION | 2002-04-16 | — | — | US | claimed |
| US-5897940-A | Ink jet transparencies | XEROX CORPORATION (US) | 1999-04-27 | — | — | US | claimed |
| US-5744273-A | Laminatable backing substrates containing fluoro compounds for improved toner flow | XEROX CORPORATION (US) | 1998-04-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070293490-A1 | Quinazoline Derivatives | CCNA1, CCND3, CCND2 | ALDH1A1 1976/4885TSHR 1605/4885CYP3A4 305/4885 |
| US-20130165386-A1 | QUINOLINE OR QUINAZOLINE DERIVATIVES WITH APOPTOSIS INDUCING ACTIVITY ON CELLS | CASP7, API5, BAX | ALDH1A1 4307/4885TSHR 4776/4885CYP3A4 2789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.