Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.46 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.40 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.36 |
| ▸ | NSD2 | O96028 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.35 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.35 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.35 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19465343 | 0.84 | KDM5A (0.46) | KDM4CMAPK14NSD3ALDH1A1PTGS2 | |
| SCHEMBL24185299 | 0.84 | IDO1 (0.42) | KDM2BKDM4CMAPK14NSD3ALDH1A1 | |
| SCHEMBL22144041 | 0.84 | ALDH1A1 (0.41) | KDM2BKDM4CMAPK14NSD3ALDH1A1 | |
| Hydrochloric Acid SCHEMBL22125991 | 0.82 | ALDH1A1 (0.40) | KDM2BKDM4CMAPK14NSD3ALDH1A1 | |
| SCHEMBL22143811 | 0.81 | SYK (0.38) | KDM2BKDM4CMAPK14NSD3TGFBR1 | |
| SCHEMBL26818511 | 0.79 | NPC1 (0.41) | MAPK14NSD3TGFBR1PTGS2NSD2 | |
| SCHEMBL15928096 | 0.77 | KDM2B (0.42) | KDM2BKDM4CMAPK14NSD3TGFBR1 | |
| SCHEMBL14384749 | 0.73 | KDM4C (0.48) | KDM2BKDM4CMAPK14TGFBR1ALDH1A1 | |
| SCHEMBL12491920 | 0.72 | CYP3A4 (0.47) | KDM2BKDM4CTGFBR1ALDH1A1NSD2 | |
| SCHEMBL22434890 | 0.71 | KDM2B (0.42) | KDM2BKDM4CMAPK14NSD3TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160067224-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. | 2016-03-10 | — | — | US | disclosed |
| US-9220710-B2 | Therapeutic compounds | GILEAD SCIENCES, INC. (US) | 2015-12-29 | — | — | US | disclosed |
| US-20140221421-A1 | THERAPEUTIC COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-08-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160067224-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | KDM2B 4574/4885KDM4C 4446/4885MAPK14 2773/4885 |
| US-20140221421-A1 | THERAPEUTIC COMPOUNDS | HAVCR2, SARS1, G6PD | KDM2B 4574/4885KDM4C 4446/4885MAPK14 2773/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.