Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.46 |
| ▸ | RAB9A | P51151 | 6/20 | 0.46 |
| ▸ | NPC1 | O15118 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.43 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.43 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC34A1 | Q06495 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30630435 | 0.78 | CYP2C19 (0.40) | SMN1; SMN2RAB9ANPC1L3MBTL1CYP2C19 | |
| SCHEMBL20075460 | 0.77 | MAPT (0.49) | SMN1; SMN2RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL30630601 | 0.76 | MAPT (0.43) | SMN1; SMN2RAB9ANPC1MAPTCYP2C19 | |
| SCHEMBL22621614 | 0.75 | MAPT (0.71) | SMN1; SMN2RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL15935032 | 0.74 | ELOVL1 (0.44) | SMN1; SMN2RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL11983495 | 0.73 | RAB9A (0.52) | SMN1; SMN2RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL9521754 | 0.72 | SMN1; SMN2 (0.64) | SMN1; SMN2RAB9ANPC1CYP2C19ALDH1A1 | |
| SCHEMBL24920819 | 0.71 | CYP2C19 (0.45) | SMN1; SMN2RAB9ANPC1MAPTCYP2C19 | |
| SCHEMBL15935205 | 0.71 | MAPT (0.45) | SMN1; SMN2RAB9ANPC1MAPTL3MBTL1 | |
| SCHEMBL15935163 | 0.71 | MAPT (0.45) | SMN1; SMN2RAB9ANPC1MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9708308-B2 | Factor IXa inhibitors | MERCK SHARP DOHME CORP. (US) | 2017-07-18 | — | — | US | disclosed |
| US-20150322056-A1 | Factor IXa Inhibitors | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2015-11-12 | — | — | US | disclosed |
| WO-2014120346-A1 | FACTOR IXA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2014-08-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150322056-A1 | Factor IXa Inhibitors | F9, F12, F8 | SMN1; SMN2 2530/4885RAB9A 556/4885NPC1 1192/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.