SCHEMBL15935971

SCHEMBL15935971

C/C(=N/NC(=O)c1ccc(C(=O)NCc2ccc(C(=O)NCCN3CCNCC3)cc2)s1)c1csc(-c2ccc(Br)cc2)c1O

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HASPIN Q8TF76 4/20 0.38
MMP12 P39900 1/20 0.35
ALDH1A1 P00352 1/20 0.34
ABL1 P00519 1/20 0.33
BCR P11274 1/20 0.33
ULK1 O75385 1/20 0.33
CHRM3 P20309 4/20 0.33
TSHR P16473 1/20 0.33
HDAC2 Q92769 1/20 0.33
HDAC8 Q9BY41 1/20 0.33
HDAC6 Q9UBN7 1/20 0.33
PBK Q96KB5 1/20 0.33
POLB P06746 1/20 0.32
KDM4E B2RXH2 1/20 0.32
GAA P10253 1/20 0.32
HSD17B10 Q99714 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
CAMK2D Q13557 1/20 0.32
MAPT P10636 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8593318 1.00 HASPIN (0.38) HASPINMMP12ALDH1A1ABL1BCR
SCHEMBL15935972 1.00 HASPIN (0.38) HASPINMMP12ALDH1A1ABL1BCR
SCHEMBL20458270 0.93 HASPIN (0.38) HASPINMMP12ULK1CHRM3HDAC2
SCHEMBL8590948 0.92 ALDH1A1 (0.37) HASPINMMP12ALDH1A1HDAC8HDAC6
SCHEMBL8578516 0.92 MMP12 (0.45) MMP12ALDH1A1TSHRL3MBTL1
SCHEMBL8592259 0.90 IKBKB (0.39) HASPINMMP12ULK1CHRM3POLB
SCHEMBL15936056 0.87 ALDH1A1 (0.36) ALDH1A1HDAC2HDAC8HDAC6KDM4E
SCHEMBL8573319 0.87 ALDH1A1 (0.36) ALDH1A1HDAC2HDAC8HDAC6KDM4E
SCHEMBL15936057 0.87 ALDH1A1 (0.36) ALDH1A1HDAC2HDAC8HDAC6KDM4E
SCHEMBL13090239 0.84 KMT2A (0.36) ALDH1A1KDM4EGAAMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2765187-B1 METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS NISSAN CHEMICAL IND LTD (JP) 2018-08-08 EP claimed
US-20140227780-A1 METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-08-14 US claimed
EP-2765187-A1 METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS Nissan Chemical Industries, Ltd. (JP) 2014-08-13 EP claimed
US-20140227780-A1 METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-08-14 US disclosed
EP-2765187-A1 METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS Nissan Chemical Industries, Ltd. (JP) 2014-08-13 EP disclosed