Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.32 |
| ▸ | MMP3 | P08254 | 2/20 | 0.32 |
| ▸ | MMP9 | P14780 | 2/20 | 0.32 |
| ▸ | MMP13 | P45452 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | FAAH | O00519 | 2/20 | 0.31 |
| ▸ | MGLL | Q99685 | 2/20 | 0.31 |
| ▸ | HTT | P42858 | 3/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP8 | P22894 | 1/20 | 0.30 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.30 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6945464 | 0.86 | PLA2G7 (0.49) | PLA2G7NR1H2NR1H3MMP2MMP3 | |
| SCHEMBL11272468 | 0.82 | MGLL (0.47) | PLA2G7NR1H2NR1H3FAAHMGLL | |
| SCHEMBL7968322 | 0.80 | PLA2G7 (0.47) | PLA2G7NR1H2NR1H3SMN1; SMN2FAAH | |
| SCHEMBL5036973 | 0.79 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP3 | |
| SCHEMBL6946605 | 0.78 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP3 | |
| SCHEMBL16674697 | 0.76 | PLA2G7 (0.44) | PLA2G7 | |
| SCHEMBL16674699 | 0.76 | MEN1 (0.47) | PLA2G7NR1H2NR1H3POLB | |
| SCHEMBL7518193 | 0.75 | PLA2G7 (0.50) | PLA2G7NR1H2NR1H3MMP2MMP3 | |
| SCHEMBL7040815 | 0.75 | PLA2G7 (0.50) | PLA2G7NR1H2NR1H3MMP2MMP3 | |
| SCHEMBL4827863 | 0.74 | PLA2G7 (0.46) | PLA2G7NR1H2NR1H3MMP2MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2248811-B1 | 2-OXOCHROMENE DERIVATIVE | KOWA CO (JP) | 2012-11-14 | — | — | EP | disclosed |
| US-7919509-B2 | 2-oxochromene derivatives | KOWA COMPANY, LTD. (JP) | 2011-04-05 | — | — | US | disclosed |
| EP-2248811-A1 | 2-OXOCHROMENE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-11-10 | — | — | EP | disclosed |
| US-20090286780-A1 | 2-OXOCHROMENE DERIVATIVES | KOWA COMPANY, LTD. (JP) | 2009-11-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090286780-A1 | 2-OXOCHROMENE DERIVATIVES | NR1H2, NR1H3, CYP46A1 | PLA2G7 1167/4885NR1H2 1/4885NR1H3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.