Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 10/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.51 |
| ▸ | NPC1 | O15118 | 3/20 | 0.51 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | XDH | P47989 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522608 | 0.84 | PIK3CG (0.70) | MEN1KMT2APIK3CGPOLBGAA | |
| SCHEMBL15940334 | 0.84 | MEN1 (0.55) | MEN1KMT2ANPC1PIK3CGPOLB | |
| SCHEMBL15940236 | 0.81 | MEN1 (0.50) | MEN1KMT2ANPC1PIK3CGPOLB | |
| SCHEMBL5960356 | 0.75 | PIK3CG (0.59) | MEN1KMT2APIK3CGPOLBGAA | |
| SCHEMBL2835916 | 0.73 | PIK3CG (0.55) | MEN1KMT2ANPC1PIK3CGPOLB | |
| SCHEMBL15940390 | 0.72 | MEN1 (0.53) | MEN1KMT2ANPC1POLBGAA | |
| SCHEMBL2835239 | 0.71 | PIK3CG (0.64) | MEN1KMT2APIK3CGPOLBGAA | |
| SCHEMBL4520112 | 0.70 | PIK3CG (0.70) | MEN1KMT2APIK3CGPOLBGAA | |
| SCHEMBL4527821 | 0.69 | PIK3CG (0.73) | MEN1KMT2APIK3CGPOLBGAA | |
| SCHEMBL15940392 | 0.69 | MAPT (0.55) | MEN1KMT2ANPC1PIK3CGPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | MERCK SERONO S.A. (CH) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228365-A1 | THIAZOLE DERIVATIVES AND USE THEREOF | PF4, TEC, PDGFRB | MEN1 1164/4885KMT2A 4760/4885NPC1 3795/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.