Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | LDHA | P00338 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15940809 | 1.00 | KMT2A (0.47) | KMT2ATSHRMAPK10LDHAMEN1 | |
| SCHEMBL14521458 | 0.81 | KMT2A (0.52) | KMT2ATSHRMAPK10LDHAMEN1 | |
| SCHEMBL15338710 | 0.78 | KMT2A (0.50) | KMT2ATSHRMAPK10LDHAMEN1 | |
| SCHEMBL15940877 | 0.77 | CTSS (0.44) | KMT2ALDHAMEN1LMNAALDH1A1 | |
| SCHEMBL9162838 | 0.75 | ALDH1A1 (0.54) | KMT2ATSHRMAPK10MEN1KDM4E | |
| SCHEMBL9162835 | 0.75 | ALDH1A1 (0.54) | KMT2ATSHRMAPK10MEN1KDM4E | |
| SCHEMBL6041188 | 0.74 | TSHR (0.62) | KMT2ATSHRMAPK10LDHAMEN1 | |
| SCHEMBL15941163 | 0.74 | SMN1; SMN2 (0.53) | LMNAALDH1A1POLBRAB9ATDP1 | |
| SCHEMBL18415450 | 0.74 | MEN1 (0.58) | KMT2ATSHRMAPK10MEN1KDM4E | |
| SCHEMBL5669243 | 0.73 | TSHR (0.59) | KMT2ATSHRMAPK10LDHAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2953932-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | Merck Patent GmbH (DE) | 2015-12-16 | — | — | EP | disclosed |
| WO-2014121884-A1 | SUBSTITUTED CARBOXYLIC ACID DERIVATIVES AS AGGRECANASE INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2014-08-14 | — | — | WO | disclosed |