Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CREBBP | Q92793 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10497745 | 0.83 | KMT2A (0.55) | CREBBPL3MBTL1SMN1; SMN2GAAKMT2A | |
| SCHEMBL12966511 | 0.80 | THRA (0.58) | CREBBPL3MBTL1SMN1; SMN2GAA | |
| SCHEMBL8265731 | 0.80 | CREBBP (0.50) | CREBBPL3MBTL1SMN1; SMN2GAAHPGD | |
| SCHEMBL10260429 | 0.79 | KMT2A (0.66) | HPGDLMNARAB9AFAAHKMT2A | |
| SCHEMBL6588516 | 0.79 | SMPD1 (0.64) | FAAHKMT2ASMPD1 | |
| SCHEMBL8393532 | 0.79 | THRA (0.59) | CREBBPL3MBTL1SMN1; SMN2GAAHPGD | |
| SCHEMBL14469762 | 0.79 | CREBBP (0.49) | CREBBPL3MBTL1SMN1; SMN2GAAHPGD | |
| SCHEMBL13219861 | 0.78 | ALDH1A1 (0.51) | CREBBPL3MBTL1SMN1; SMN2GAAHPGD | |
| SCHEMBL6200527 | 0.78 | PTPN11 (0.63) | CREBBPHPGDALDH1A1 | |
| SCHEMBL14667298 | 0.78 | SMN1; SMN2 (0.56) | CREBBPL3MBTL1SMN1; SMN2GAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2764866-A1 | Inhibitors of nedd8-activating enzyme | IP Gesellschaft für Management mbH (DE) | 2014-08-13 | — | — | EP | disclosed |