Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 3/20 | 0.40 |
| ▸ | PPARA | Q07869 | 3/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | LSS | P48449 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 2/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | CPA1 | P15085 | 1/20 | 0.38 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1594483 | 1.00 | PPARG (0.40) | PPARGPPARAEPHX2SLC6A9LSS | |
| SCHEMBL532696 | 0.84 | HPGD (0.45) | SLC6A2SLC6A4MMEMEN1KMT2A | |
| SCHEMBL640803 | 0.84 | HPGD (0.45) | SLC6A2SLC6A4MMEMEN1KMT2A | |
| SCHEMBL531678 | 0.84 | HPGD (0.45) | SLC6A2SLC6A4MMEMEN1KMT2A | |
| SCHEMBL531859 | 0.84 | HPGD (0.45) | SLC6A2SLC6A4MMEMEN1KMT2A | |
| SCHEMBL5753177 | 0.83 | NOS3 (0.39) | PPARGPPARAEPHX2SLC6A9CES2 | |
| SCHEMBL18920594 | 0.80 | MAOB (0.43) | EPHX2SLC6A2SLC6A4ACEMEN1 | |
| SCHEMBL21144939 | 0.80 | MAOB (0.43) | EPHX2SLC6A2SLC6A4ACEMEN1 | |
| SCHEMBL5749557 | 0.78 | FFAR2 (0.42) | PPARGPPARASLC6A9CES2CES1 | |
| SCHEMBL5751305 | 0.78 | PPARG (0.36) | PPARGPPARASLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919504-B2 | Thiadiazole modulators of PKB | AMGEN INC. (US) | 2011-04-05 | — | — | US | disclosed |