Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | PLOD2 | O00469 | 1/20 | 0.46 |
| ▸ | PLOD3 | O60568 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | PLOD1 | Q02809 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.41 |
| ▸ | CCR5 | P51681 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | PRCP | P42785 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL369594 | 0.85 | ALDH1A1 (0.61) | ALDH1A1PLOD2PLOD3CYP1A2CYP3A4 | |
| SCHEMBL368510 | 0.82 | GPBAR1 (0.64) | TRPV6ALDH1A1KDM4ERECQLEPHX2 | |
| SCHEMBL368509 | 0.82 | GPBAR1 (0.64) | TRPV6ALDH1A1KDM4ERECQLEPHX2 | |
| SCHEMBL363733 | 0.82 | GPBAR1 (0.64) | TRPV6ALDH1A1KDM4ERECQLEPHX2 | |
| SCHEMBL364507 | 0.80 | MGAM (0.52) | ALDH1A1PLOD2PLOD3CYP1A2CYP3A4 | |
| SCHEMBL369701 | 0.77 | GPBAR1 (0.68) | ALDH1A1PLOD2PLOD3CYP1A2CYP3A4 | |
| SCHEMBL15949141 | 0.76 | PLOD2 (0.46) | ALDH1A1PLOD2PLOD3CYP1A2CYP3A4 | |
| SCHEMBL15949109 | 0.76 | HPGD (0.46) | ALDH1A1PLOD2PLOD3CYP1A2CYP3A4 | |
| SCHEMBL364446 | 0.74 | MGAM (0.55) | ALDH1A1PLOD2PLOD3CYP1A2CYP3A4 | |
| SCHEMBL6200667 | 0.74 | TSHR (0.63) | ALDH1A1CYP1A2CYP3A4CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | claimed |
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |