Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | CASP7 | P55210 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | PKLR | P30613 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL693935 | 0.92 | CYP3A4 (0.53) | ALDH1A1SMN1; SMN2HSD11B1HPGDCASP1 | |
| SCHEMBL15949455 | 0.87 | CACNA1B (0.47) | ALDH1A1SMN1; SMN2HSD11B1HPGDCASP1 | |
| SCHEMBL694019 | 0.84 | MGLL (0.50) | ALDH1A1SMN1; SMN2HSD11B1HPGDCASP1 | |
| SCHEMBL693719 | 0.84 | MGLL (0.54) | ALDH1A1SMN1; SMN2HSD11B1HPGDCASP1 | |
| SCHEMBL15949406 | 0.79 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2HSD11B1HPGDLMNA | |
| SCHEMBL913340 | 0.78 | MGLL (0.56) | ALDH1A1SMN1; SMN2HSD11B1HPGDCASP1 | |
| SCHEMBL15949446 | 0.78 | MGLL (0.53) | HSD11B1HPGDLMNAMGLLPOLB | |
| SCHEMBL912310 | 0.76 | MGLL (0.50) | MGLLGAACYP3A4CYP2C19RXFP1 | |
| SCHEMBL912390 | 0.76 | MGLL (0.54) | ALDH1A1SMN1; SMN2HSD11B1HPGDCASP1 | |
| SCHEMBL15949273 | 0.76 | CA12 (0.47) | ALDH1A1SMN1; SMN2HSD11B1HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |