Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 3/20 | 0.70 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | ACACB | O00763 | 8/20 | 0.57 |
| ▸ | ACACA | Q13085 | 8/20 | 0.57 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.53 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.50 |
| ▸ | MGLL | Q99685 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949386 | 0.95 | FASN (0.74) | FASNSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL15949315 | 0.95 | FASN (0.79) | FASNSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL15949476 | 0.88 | HPGD (0.62) | FASNSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL912172 | 0.85 | SLC6A7 (0.55) | FASNSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL911620 | 0.83 | MEN1 (0.66) | FASNHPGDMEN1KMT2AL3MBTL3 | |
| SCHEMBL911925 | 0.83 | FASN (0.51) | FASNSMN1; SMN2HPGDMEN1KMT2A | |
| SCHEMBL915762 | 0.82 | KDM4E (0.56) | FASNMEN1KMT2AACACBACACA | |
| SCHEMBL911524 | 0.81 | ABL1 (0.61) | FASNHPGDTSHRACACBACACA | |
| SCHEMBL15949361 | 0.81 | L3MBTL3 (0.56) | FASNHPGDMEN1KMT2AACACB | |
| SCHEMBL15949266 | 0.81 | POLB (0.56) | FASNHPGDMEN1KMT2AACACB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |