Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 4/20 | 0.40 |
| ▸ | GHSR | Q92847 | 1/20 | 0.39 |
| ▸ | SLC6A7 | Q99884 | 4/20 | 0.39 |
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | BCR | P11274 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911330 | 0.85 | MGLL (0.52) | ALDH1A1POLBMGLLSLC6A7L3MBTL3 | |
| SCHEMBL911498 | 0.83 | ALDH1A1 (0.60) | HSP90AA1ALDH1A1MAPTPKMPOLB | |
| SCHEMBL911934 | 0.82 | MGLL (0.54) | POLBMGLLSLC6A7L3MBTL3L3MBTL1 | |
| SCHEMBL14647954 | 0.82 | MGLL (0.54) | MGLLSLC6A7 | |
| SCHEMBL15949392 | 0.82 | MGLL (0.54) | POLBMGLLSLC6A7L3MBTL3L3MBTL1 | |
| SCHEMBL913138 | 0.82 | MGLL (0.54) | MGLLSLC6A7 | |
| SCHEMBL912812 | 0.80 | CA12 (0.44) | MGLLGHSRSLC6A7L3MBTL3L3MBTL1 | |
| SCHEMBL15949366 | 0.80 | CA12 (0.44) | MGLLGHSRSLC6A7L3MBTL3L3MBTL1 | |
| SCHEMBL693717 | 0.76 | MGLL (0.56) | ALDH1A1POLBMGLLSLC6A7 | |
| SCHEMBL693446 | 0.73 | KDM4E (0.50) | ALDH1A1POLBMGLLL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |