Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 7/20 | 0.57 |
| ▸ | GPR52 | Q9Y2T5 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | BCR | P11274 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912450 | 0.91 | MGLL (0.60) | MGLLPOLBSLC6A7MAPK10 | |
| SCHEMBL15949209 | 0.91 | MGLL (0.60) | MGLLPOLBSLC6A7MAPK10 | |
| SCHEMBL14648051 | 0.89 | MGLL (0.54) | MGLLPOLBSLC6A7ABL1BCR | |
| SCHEMBL14877410 | 0.88 | GPR52 (0.49) | MGLLGPR52SLC6A7 | |
| SCHEMBL912390 | 0.88 | MGLL (0.54) | MGLLPOLBABL1BCR | |
| SCHEMBL911839 | 0.87 | MGLL (0.60) | MGLLPOLBSLC6A7ABL1BCR | |
| SCHEMBL911158 | 0.87 | MGLL (0.60) | MGLLPOLBSLC6A7ABL1BCR | |
| SCHEMBL693719 | 0.86 | MGLL (0.54) | MGLLABL1BCR | |
| SCHEMBL15196702 | 0.86 | MGLL (0.57) | MGLLGPR52POLBMAPK8MAPK10 | |
| SCHEMBL694296 | 0.85 | MGLL (0.60) | MGLLPOLBSLC6A7ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |