Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 5/20 | 0.57 |
| ▸ | ACACB | O00763 | 2/20 | 0.51 |
| ▸ | ACACA | Q13085 | 2/20 | 0.51 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949373 | 0.88 | MGLL (0.53) | MGLLACACBACACAL3MBTL3L3MBTL1 | |
| SCHEMBL15949436 | 0.86 | MGLL (0.54) | MGLLACACBACACAL3MBTL3L3MBTL1 | |
| SCHEMBL911861 | 0.85 | MGLL (0.66) | MGLL | |
| SCHEMBL911584 | 0.85 | MGLL (0.66) | MGLLACACBACACAL3MBTL3L3MBTL1 | |
| SCHEMBL3784571 | 0.85 | MGLL (0.58) | MGLLL3MBTL1KDM4EALDH1A1 | |
| SCHEMBL3771233 | 0.84 | MGLL (0.57) | MGLLACACBACACAL3MBTL3L3MBTL1 | |
| SCHEMBL15949430 | 0.84 | ALDH1A1 (0.58) | MGLLACACBACACAKDM4EALDH1A1 | |
| SCHEMBL911565 | 0.84 | HTT (0.63) | MGLLKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL911264 | 0.84 | HTT (0.63) | MGLLKDM4EALDH1A1HTTMEN1 | |
| SCHEMBL15949476 | 0.84 | HPGD (0.62) | MGLLACACBACACAL3MBTL3L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |