Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.58 |
| ▸ | TRPV6 | Q9H1D0 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | MGLL | Q99685 | 4/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GPR6 | P46095 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15949293 | 0.87 | KMT2A (0.59) | ALDH1A1KDM4ETRPV6CYP1A2MGLL | |
| SCHEMBL15949460 | 0.87 | ALDH1A1 (0.58) | ALDH1A1KDM4ETRPV6CYP1A2MGLL | |
| SCHEMBL15949448 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETRPV6CYP1A2MGLL | |
| SCHEMBL15949430 | 0.84 | ALDH1A1 (0.58) | ALDH1A1KDM4ETRPV6CYP1A2MGLL | |
| SCHEMBL14647938 | 0.83 | ALDH1A1 (0.51) | ALDH1A1KDM4EMGLLKMT2AMEN1 | |
| SCHEMBL15949403 | 0.83 | HRH3 (0.54) | ALDH1A1KDM4EMGLLKMT2AMEN1 | |
| SCHEMBL911026 | 0.82 | ALDH1A1 (0.49) | ALDH1A1KDM4ETRPV6CYP1A2MGLL | |
| SCHEMBL14648011 | 0.82 | HPGD (0.52) | ALDH1A1KDM4EMGLLKMT2AMEN1 | |
| SCHEMBL911597 | 0.82 | ALDH1A1 (0.53) | ALDH1A1KDM4ETRPV6CYP1A2MGLL | |
| SCHEMBL694035 | 0.81 | KCNH2 (0.61) | ALDH1A1KDM4EMGLLHPGDLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |