Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.54 |
| ▸ | MGLL | Q99685 | 6/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TACR3 | P29371 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL912315 | 0.89 | MGLL (0.55) | HRH3MGLL | |
| SCHEMBL15949393 | 0.89 | MGLL (0.52) | HRH3MGLLALDH1A1MEN1KMT2A | |
| SCHEMBL14647938 | 0.85 | ALDH1A1 (0.51) | MGLLALDH1A1LMNAMAPTTSHR | |
| SCHEMBL912159 | 0.85 | HRH3 (0.57) | HRH3MGLLALDH1A1MAPTHTT | |
| SCHEMBL15949467 | 0.83 | ALDH1A1 (0.58) | MGLLALDH1A1LMNATSHRMEN1 | |
| SCHEMBL911777 | 0.82 | HRH3 (0.78) | HRH3MGLL | |
| SCHEMBL14648127 | 0.81 | HPGD (0.52) | MGLLALDH1A1LMNAMAPTTSHR | |
| SCHEMBL14648130 | 0.79 | MGLL (0.53) | MGLLALDH1A1LMNAMAPTTSHR | |
| SCHEMBL14648011 | 0.78 | HPGD (0.52) | HRH3MGLLALDH1A1LMNAMAPT | |
| SCHEMBL912292 | 0.78 | MGLL (0.55) | MGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421823-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2015-01-14 | — | — | EP | disclosed |
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |