Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 16/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.47 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.47 |
| ▸ | PIM1 | P11309 | 1/20 | 0.47 |
| ▸ | CDK8 | P49336 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | CDK7 | P50613 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1595054 | 1.00 | TRPV1 (0.48) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1593920 | 0.93 | TRPV1 (0.56) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1593916 | 0.93 | TRPV1 (0.56) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1594987 | 0.92 | TRPV1 (0.47) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1595623 | 0.92 | TRPV1 (0.47) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1595619 | 0.92 | TRPV1 (0.47) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1594985 | 0.92 | TRPV1 (0.47) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1594852 | 0.92 | TRPV1 (0.48) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1594848 | 0.92 | TRPV1 (0.48) | TRPV1ROCK1CHEK1PIM1CDK8 | |
| SCHEMBL1593602 | 0.88 | TRPV1 (0.53) | TRPV1ROCK1CHEK1PIM1CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7919624-B2 | VR1 vanilloid receptor antagonists with a iononic substructure | PHARMESTE S.R.L. (IT) | 2011-04-05 | — | — | US | disclosed |
| EP-2046752-B1 | VR1 VANILLOID RECEPTOR ANTAGONISTS WITH A IONONIC SUBSTRUCTURE | PHARMESTE SRL (IT) | 2010-05-19 | — | — | EP | disclosed |
| US-20100035923-A1 | VR1 VANILLOID RECEPTOR ANTAGONISTS WITH A IONONIC SUBSTRUCTURE | PHARMESTE S.R.L. (IT) | 2010-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100035923-A1 | VR1 VANILLOID RECEPTOR ANTAGONISTS WITH A IONONIC SUBSTRUCTURE | TRPV1, TRPV6, TRPV2 | TRPV1 1/4885ROCK1 2059/4885CHEK1 4815/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.