Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | XDH | P47989 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 2/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.42 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TTK | P33981 | 1/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetoacetic Acid SCHEMBL27602459 | 0.91 | KDM4E (0.42) | KDM4EXDHPDE4BARMAPK8 | |
| SCHEMBL27935121 | 0.86 | KDM4E (0.56) | KDM4EARCYP3A4TSHRMAPT | |
| SCHEMBL2723599 | 0.83 | AR (0.56) | KDM4EARMAPTMAPK1NPC1 | |
| SCHEMBL4673630 | 0.82 | KDM4E (0.51) | KDM4EXDHARTSHRMAPT | |
| SCHEMBL6615190 | 0.81 | KDM4E (0.54) | KDM4ECYP3A4TSHRMAPTMAPK1 | |
| SCHEMBL9150083 | 0.80 | KDM4E (0.56) | KDM4ECYP3A4TSHRMAPTMAPK1 | |
| SCHEMBL973000 | 0.80 | AR (0.51) | KDM4EPDE4BARMAPK8MAPK9 | |
| SCHEMBL21728056 | 0.78 | LMNA (0.43) | KDM4EARCYP3A4MAPTMAPK1 | |
| SCHEMBL15205062 | 0.78 | KDM4E (0.44) | KDM4EARCYP3A4MAPTMAPK1 | |
| SCHEMBL6908590 | 0.77 | KDM4E (0.76) | KDM4ECYP3A4TSHRMAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956142-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | Merck Sharp & Dohme Corp. (US) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014126944-A2 | INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL | MERCK SHARP & DOHME CORP. (US) | 2014-08-21 | — | — | WO | disclosed |