Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 6/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 6/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.42 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.42 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.42 |
| ▸ | CHRNA1 | P02708 | 4/20 | 0.42 |
| ▸ | CHRNG | P07510 | 4/20 | 0.42 |
| ▸ | CHRNB1 | P11230 | 4/20 | 0.42 |
| ▸ | CHRND | Q07001 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 2/20 | 0.40 |
| ▸ | DPP7 | Q9UHL4 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | FDPS | P14324 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14655308 | 1.00 | MAOB (0.43) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL1303845 | 1.00 | MAOB (0.43) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL17331175 | 1.00 | MAOB (0.43) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL1303572 | 0.98 | ATM (0.41) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL1613168 | 0.98 | ATM (0.41) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL19517200 | 0.98 | ATM (0.41) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL8695815 | 0.93 | — | — | |
| SCHEMBL16026595 | 0.87 | MEN1 (0.37) | MAOBSLC6A2CHRNB4CHRNA3SLC6A3 | |
| SCHEMBL30018449 | 0.81 | KDM4E (0.43) | MAOBSLC6A2SLC6A3ALDH1A1KDM4E | |
| SCHEMBL23278004 | 0.81 | HRH3 (0.39) | ALDH1A1KDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10913726-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-02-09 | — | — | US | disclosed |
| US-10913726-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-02-09 | — | — | US | disclosed |
| US-10800749-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2020-10-13 | — | — | US | disclosed |
| US-20190337911-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-11-07 | — | — | US | disclosed |
| US-20190119237-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-25 | — | — | US | disclosed |
| US-20190119237-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2019-04-25 | — | — | US | disclosed |
| EP-2956451-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | The Regents of the University of California (US) | 2015-12-23 | — | — | EP | disclosed |
| US-20150361060-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-12-17 | — | — | US | disclosed |
| US-20150361060-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2015-12-17 | — | — | US | disclosed |
| WO-2014127315-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-21 | — | — | WO | disclosed |
| WO-2014127315-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10800749-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | ACHE, BCHE, IDE | MAOB 1005/4885SLC6A2 466/4885CHRNB4 83/4885 |
| US-20190337911-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | ACHE, BCHE, IDE | MAOB 1005/4885SLC6A2 466/4885CHRNB4 83/4885 |
| US-20150361060-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | ACHE, BCHE, IDE | MAOB 1005/4885SLC6A2 466/4885CHRNB4 83/4885 |
| US-20190119237-A1 | CENTRALLY ACTIVE AND ORALLY BIOAVAILABLE ANTIDOTES FOR ORGANOPHOSPHATE EXPOSURE AND METHODS FOR MAKING AND USING THEM | ACHE, BCHE, IDE | MAOB 1005/4885SLC6A2 466/4885CHRNB4 83/4885 |
| US-10913726-B2 | Centrally active and orally bioavailable antidotes for organophosphate exposure and methods for making and using them | ACHE, BCHE, IDE | MAOB 1005/4885SLC6A2 466/4885CHRNB4 83/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.