Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 14/20 | 0.61 |
| ▸ | PYGL | P06737 | 5/20 | 0.47 |
| ▸ | PYGM | P11217 | 5/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15964542 | 0.83 | RIPK1 (0.53) | RIPK1PYGLPYGM | |
| SCHEMBL21307195 | 0.81 | RIPK1 (0.59) | RIPK1PYGLPYGM | |
| SCHEMBL17312688 | 0.81 | RIPK1 (0.59) | RIPK1PYGLPYGM | |
| SCHEMBL17312692 | 0.81 | RIPK1 (0.59) | RIPK1PYGLPYGM | |
| SCHEMBL4214219 | 0.81 | RIPK1 (0.61) | RIPK1PYGLPYGMDDB1CRBN | |
| SCHEMBL3924254 | 0.81 | RIPK1 (0.61) | RIPK1PYGLPYGMDDB1CRBN | |
| SCHEMBL21144873 | 0.80 | PYGL (0.45) | RIPK1PYGLPYGM | |
| SCHEMBL23447199 | 0.79 | RIPK1 (0.86) | RIPK1 | |
| SCHEMBL3989268 | 0.79 | PYGL (0.53) | RIPK1PYGLPYGMDDB1CRBN | |
| SCHEMBL3914513 | 0.79 | PYGL (0.53) | RIPK1PYGLPYGMDDB1CRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014125444-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-08-21 | — | — | WO | disclosed |