Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NISCH | Q9Y2I1 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 2/20 | 0.39 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.39 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.39 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28410901 | 1.00 | NISCH (0.42) | NISCHSMN1; SMN2CHRNB4CHRNA3CHRNB2 | |
| SCHEMBL30728630 | 0.79 | BLM (0.37) | — | |
| SCHEMBL30728617 | 0.79 | BLM (0.37) | — | |
| SCHEMBL4700749 | 0.77 | NISCH (0.37) | NISCHMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL22482352 | 0.77 | KDM1A (0.32) | NISCHCHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL18365855 | 0.77 | ABCG2 (0.50) | NISCHSMN1; SMN2 | |
| SCHEMBL30076378 | 0.74 | ADRA1A (0.35) | NISCHSMN1; SMN2MEN1KMT2A | |
| SCHEMBL30250644 | 0.74 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL31025716 | 0.74 | CHRNB4 (0.36) | CHRNB4CHRNA3CHRNB2CHRNA4 | |
| SCHEMBL30250553 | 0.74 | NISCH (0.44) | NISCH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2956452-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2015-12-23 | — | — | EP | disclosed |
| WO-2014125444-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2014-08-21 | — | — | WO | disclosed |