Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15958477 | 1.00 | CRBN (0.52) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL15958467 | 0.92 | MAPT (0.56) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL15958469 | 0.92 | MAPT (0.56) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL15958457 | 0.91 | MAPT (0.58) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL15958456 | 0.89 | MAPT (0.51) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL2230536 | 0.79 | MAPT (0.58) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL22466180 | 0.78 | MAPT (0.57) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL22466224 | 0.78 | SIRT6 (0.58) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL27625331 | 0.78 | SIRT6 (0.54) | CRBNMAPTSIRT6ALDH1A1POLB | |
| SCHEMBL22466069 | 0.77 | POLB (0.57) | CRBNMAPTSIRT6ALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2867238-B1 | PHENYL AMINO PYRIMIDINE BICYCLIC COMPOUNDS AND USES THEREOF | YM BIOSCIENCES AUSTRALIA PTY (AU) | 2017-08-09 | — | — | EP | disclosed |
| US-8809359-B2 | Phenyl amino pyrimidine bicyclic compounds and uses thereof | YM BIOSCIENCES AUSTRALIA PTY LTD (US) | 2014-08-19 | — | — | US | disclosed |