Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.54 |
| ▸ | MAPT | P10636 | 8/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27694801 | 0.81 | POLB (0.65) | SIRT6MAPTALDH1A1POLBSMN1; SMN2 | |
| SCHEMBL27969501 | 0.79 | ALDH1A1 (0.67) | MAPTALDH1A1POLBLMNACRBN | |
| SCHEMBL18436557 | 0.79 | ADRB1 (0.43) | MAPTALDH1A1POLBADRB1AKR1C3 | |
| SCHEMBL85548 | 0.79 | AKR1C3 (0.71) | SIRT6MAPTALDH1A1POLBADRB1 | |
| SCHEMBL15958477 | 0.78 | CRBN (0.52) | SIRT6MAPTALDH1A1POLBADRB1 | |
| SCHEMBL15958475 | 0.78 | CRBN (0.52) | SIRT6MAPTALDH1A1POLBADRB1 | |
| SCHEMBL6624674 | 0.78 | MAPT (0.46) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL31276657 | 0.78 | AKR1C3 (0.41) | MAPTALDH1A1POLBAKR1C3SMN1; SMN2 | |
| SCHEMBL18436319 | 0.77 | LMNA (0.52) | MAPTALDH1A1POLBLMNASMN1; SMN2 | |
| SCHEMBL1399562 | 0.77 | SIRT6 (0.64) | SIRT6MAPTALDH1A1POLBADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1738615-A | Diaminotriazoles as inhibitors of protein kinases | VERTEX PHARMA (US) | 2006-02-22 | — | — | CN | disclosed |