Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | PARP1 | P09874 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.36 |
| ▸ | CDC25B | P30305 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | CASP6 | P55212 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.36 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15184305 | 0.88 | MAPT (0.40) | MAPTPARP1SMN1; SMN2TP53ALDH1A1 | |
| SCHEMBL2320352 | 0.88 | PARP1 (0.42) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL2320356 | 0.88 | PARP1 (0.42) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL2319459 | 0.88 | PARP1 (0.38) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL15958208 | 0.85 | KDM4E (0.39) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1038155 | 0.78 | PARP1 (0.40) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL1343569 | 0.78 | PARP1 (0.40) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL987844 | 0.77 | PARP1 (0.39) | MAPTPARP1SMN1; SMN2TSHRALDH1A1 | |
| SCHEMBL989215 | 0.77 | MAPT (0.38) | MAPTPARP1SMN1; SMN2ALDH1A1TNKS | |
| SCHEMBL988880 | 0.76 | MAPT (0.37) | MAPTPARP1SMN1; SMN2ALDH1A1TNKS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809526-B2 | Synthesis of cyclopentaquinazolines | ONYX PHARMACEUTICALS, INC. (US) | 2014-08-19 | — | — | US | disclosed |