Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | TNKS | O95271 | 3/20 | 0.36 |
| ▸ | TNKS2 | Q9H2K2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL987842 | 1.00 | PARP1 (0.39) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL988879 | 0.91 | MAPT (0.37) | PARP1KDM4ETNKSTNKS2ALDH1A1 | |
| SCHEMBL988880 | 0.91 | MAPT (0.37) | PARP1KDM4ETNKSTNKS2ALDH1A1 | |
| SCHEMBL1038155 | 0.89 | PARP1 (0.40) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL1343569 | 0.89 | PARP1 (0.40) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL1544255 | 0.89 | PARP1 (0.40) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL3674777 | 0.85 | KDM4E (0.43) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL3674775 | 0.85 | KDM4E (0.43) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL2320352 | 0.84 | PARP1 (0.42) | PARP1KDM4ERECQLTNKSTNKS2 | |
| SCHEMBL2320356 | 0.84 | PARP1 (0.42) | PARP1KDM4ERECQLTNKSTNKS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2213664-B1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG INT LTD (GB) | 2014-04-30 | — | — | EP | disclosed |
| US-8486955-B2 | Anti-cancer cyclopenta [g] quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2013-07-16 | — | — | US | disclosed |
| US-8063056-B2 | Anti-cancer cyclopenta [g]quinazonline compounds | BTG INTERNATIONAL LIMITED (GB) | 2011-11-22 | — | — | US | disclosed |
| EP-1420809-B1 | USE OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES FOR TREATING CANCER | BTG INT LTD (GB) | 2011-09-28 | — | — | EP | disclosed |
| EP-2332962-A1 | Cyclopenta[g]quinazoline compounds for use in the treatment of inflammatory or allergic conditions | BTG International Limited (GB) | 2011-06-15 | — | — | EP | disclosed |
| EP-2311850-A1 | Anti-cancer cyclopenta[g]quinazoline compounds | BTG International Limited (GB) | 2011-04-20 | — | — | EP | disclosed |
| US-7863284-B2 | Anti-cancer cyclopenta[G]quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2011-01-04 | — | — | US | disclosed |
| EP-1421105-B1 | ANTI-CANCER CYCLOPENTA¬G QUINAZOLINE COMPOUNDS | BTG INT LTD (GB) | 2010-10-06 | — | — | EP | disclosed |
| US-20100216824-A1 | Anti-cancer cyclopenta [G]quinazonline compounds | BTG INTERNATIONAL LIMITED (GB) | 2010-08-26 | — | — | US | disclosed |
| EP-2213664-A1 | PROCESS FOR THE PREPARATION OF CYCLOPENTA[G]QUINAZOLINE DERIVATIVES | BTG International Limited (GB) | 2010-08-04 | — | — | EP | disclosed |
| US-7705006-B2 | Anti-cancer cyclopenta[g]quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2010-04-27 | — | — | US | disclosed |
| US-20100056551-A1 | Anti-cancer cyclopenta [G] quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2010-03-04 | — | — | US | disclosed |
| US-7528141-B2 | Use of cyclopenta[g]quinazoline derivatives for treating cancer | BTG INTERNATIONAL LIMITED (GB) | 2009-05-05 | — | — | US | disclosed |
| US-20090023760-A1 | Anti-cancer cyclopenta[G]quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2009-01-22 | — | — | US | disclosed |
| US-20080015206-A1 | Anti-cancer cyclopenta[G]quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2008-01-17 | — | — | US | disclosed |
| US-7297701-B2 | Anti-cancer cyclopenta [G]quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2007-11-20 | — | — | US | disclosed |
| US-7250511-B2 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2007-07-31 | — | — | US | disclosed |
| US-20050009851-A1 | Use of cyclopeta[g]quinazoline derivatives for treating cancer | BTG INTERNATIONAL LIMITED (GB) | 2005-01-13 | — | — | US | disclosed |
| US-20040266798-A1 | Process for the preparation of cyclopenta[g]quinazoline derivatives | BTG INTERNATIONAL LIMITED (GB) | 2004-12-30 | — | — | US | disclosed |
| US-20040242606-A1 | Anti-cancer cyclopenta (g)quinazoline compounds | BTG INTERNATIONAL LIMITED (GB) | 2004-12-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056551-A1 | Anti-cancer cyclopenta [G] quinazoline compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NR0B1, CNR1 | PARP1 342/4885KDM4E 2730/4885RECQL 219/4885 |
| US-20040266798-A1 | Process for the preparation of cyclopenta[g]quinazoline derivatives | COX6A1, MT-ND6, CYP2D6 | PARP1 745/4885KDM4E 2594/4885RECQL 253/4885 |
| US-20040242606-A1 | Anti-cancer cyclopenta (g)quinazoline compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CBR1, NR4A1 | PARP1 137/4885KDM4E 1184/4885RECQL 543/4885 |
| US-20050009851-A1 | Use of cyclopeta[g]quinazoline derivatives for treating cancer | CNR1, NR3C1, NR0B1 | PARP1 1111/4885KDM4E 4184/4885RECQL 633/4885 |
| US-20080015206-A1 | Anti-cancer cyclopenta[G]quinazoline compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NR0B1, CNR1 | PARP1 510/4885KDM4E 2786/4885RECQL 340/4885 |
| US-20100216824-A1 | Anti-cancer cyclopenta [G]quinazonline compounds | NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, CNR1 | PARP1 608/4885KDM4E 2768/4885RECQL 451/4885 |
| US-20090023760-A1 | Anti-cancer cyclopenta[G]quinazoline compounds | H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NR0B1, CNR1 | PARP1 467/4885KDM4E 2768/4885RECQL 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.