Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 2/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.48 |
| ▸ | PDK3 | Q15120 | 2/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 2/20 | 0.48 |
| ▸ | HSD17B3 | P37058 | 5/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.37 |
| ▸ | TUBB | P07437 | 1/20 | 0.37 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.37 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.37 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.37 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.37 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.37 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.37 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.37 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.37 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.37 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.37 |
| ▸ | TUBB6 | Q9BUF5 | 1/20 | 0.37 |
| ▸ | TUBB2B | Q9BVA1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL911935 | 0.90 | PDK1 (0.49) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL699899 | 0.84 | PDK1 (0.46) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL30366579 | 0.82 | PDK1 (0.64) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL16586031 | 0.82 | PDK1 (0.64) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL17018033 | 0.82 | PDK1 (0.64) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL6840317 | 0.76 | FAAH (0.40) | PDK1PDK2PDK3PDK4TUBB4A | |
| SCHEMBL697100 | 0.74 | PDK1 (0.39) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL26080610 | 0.73 | NOTUM (0.62) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL26071790 | 0.73 | NOTUM (0.62) | PDK1PDK2PDK3PDK4HSD17B3 | |
| SCHEMBL697653 | 0.72 | FAAH (0.37) | PDK1PDK2PDK3PDK4HSD17B3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2421825-B9 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-08-20 | — | — | EP | disclosed |
| EP-2421825-B1 | AZETIDINYL DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS | JANSSEN PHARMACEUTICA NV (BE) | 2014-01-01 | — | — | EP | disclosed |