Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 1/20 | 0.50 |
| ▸ | TACR1 | P25103 | 2/20 | 0.49 |
| ▸ | SOS2 | Q07890 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MPO | P05164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | TNF | P01375 | 1/20 | 0.41 |
| ▸ | CLEC4M | Q9H2X3 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1595190 | 0.89 | SOS2 (0.45) | SCN9ATACR1SOS2KDM4ELMNA | |
| SCHEMBL27744607 | 0.89 | SOS2 (0.45) | SCN9ATACR1SOS2KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL3999371 | 0.88 | TACR1 (0.44) | SCN9ATACR1SOS2KDM4ELMNA | |
| SCHEMBL19846987 | 0.85 | SOS2 (0.48) | TACR1SOS2KDM4ELMNAMAPT | |
| SCHEMBL18029211 | 0.83 | MAPT (0.62) | SCN9ASOS2KDM4ELMNAMAPT | |
| SCHEMBL1594831 | 0.83 | MAPT (0.62) | SCN9ASOS2KDM4ELMNAMAPT | |
| SCHEMBL1594834 | 0.83 | MAPT (0.62) | SCN9ASOS2KDM4ELMNAMAPT | |
| SCHEMBL1594839 | 0.81 | SOS2 (0.45) | TACR1SOS2KDM4ELMNAMAPT | |
| SCHEMBL839065 | 0.80 | TACR1 (0.72) | SCN9ATACR1KDM4ELMNAMAPT | |
| SCHEMBL133958 | 0.80 | TACR1 (0.72) | SCN9ATACR1KDM4ELMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1865950-B1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | CENTRE NAT RECH SCIENT (FR) | 2013-08-28 | — | — | EP | disclosed |
| US-7919468-B2 | Compounds useful as modulators of the proteasome activity | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-04-05 | — | — | US | disclosed |
| US-7919468-B2 | Compounds useful as modulators of the proteasome activity | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) (FR) | 2011-04-05 | — | — | US | disclosed |
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | CENTRE NATIONAL DE AL RECHERCHE SCIENTIFIQUE (FR) | 2009-03-12 | — | — | US | disclosed |
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | CENTRE NATIONAL DE AL RECHERCHE SCIENTIFIQUE (FR) | 2009-03-12 | — | — | US | disclosed |
| EP-1865950-A1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | The Centre National de la Recherche Scientifique (FR) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006105811-A1 | COMPOUNDS USEFUL AS MODULATORS OF THE PROTEASOME ACTIVITY | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2006-10-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090069222-A1 | Compounds Useful as Modulators of the Proteasome Activity | PSMB10, PSMB11, PSMB6 | SCN9A 2198/4885TACR1 3193/4885SOS2 3352/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.